A team of researchers from Canada offers a new technique of multiphoton photothermolysis to selectively close single blood vessels within the tissue, using a targeted therapy by laser systems. The application of laser technology includes the treatment of different vascular diseases and dysregulated blood vessels, varying from cancers to macular degeneration to port wine birthmarks.
Such therapy treatment is based on multiphoton absorption using laser systems. The fiber laser device operation applies a targeted laser beam produced by a near-infrared femtosecond fiber laser, herewith, the beam is directed at the center of the necessary vessel.
Thus, the femtosecond laser creates localized heating that distributes to the blood vessel walls and evokes it to destroy. It should be mentioned that it is possible to induce the multiphoton absorption by the laser system only at the focal point with extremely high power density from the laser beam, that is why nearby vessels are in safe.
The femtosecond laser system is considered to be highly promising because it has such an advantage as absorption at the focal point only. Therefore, the fiber laser system allows directing the focal point with a microstructure so it is possible to treat the microstructure very accurately without any adverse effects to the nearby issue.
The researchers developed an optical system that enables imaging, targeting and closing a single blood vessel. They use a 785 nm diode laser in order to image the required blood vessel with the help of reflectance confocal microscopy and to affirm the closure of the blood vessel after its treatment.
Moreover, it should be noted that a powerful Ti: sapphire femtosecond laser tuned to 830 nm is used for the treatment procedure. And the near-infrared light from the fiber laser beam allows making deeper penetration than the visible wavelengths offer for single-photon absorption-based techniques.
The researchers have tested the laser technology on a mouse ear model, and it turns out that single vessels of different sizes, including capillaries and venules, are closed. Thus, the fiber laser device closes blood vessels deep within a tissue while saving superficial blood vessels.
Finally, this fiber laser technique is ideal for selective denaturation of certain vessels while saving other vessels to maintain normal tissue physiology once the disease is treated. Nevertheless, laser technology still requires improvements, for example, in some cases, the vessels could be partially blocked instead of completely closed.
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